Frame JD, Baldwin JM, Gocke DJ, Troup JM (1 July 1970). Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings. Am. J. Trop. Med. Hyg. 19 (4): 670–6
Ogbu O, Ajuluchukwu E, Uneke CJ (2007). Lassa fever in West African sub-region: an overview. Journal of vector borne diseases 44 (1): 1–11
Hastie, K et al. Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3′ to 5′ exonuclease activity essential for immune suppression. PNAS. 108(6):2396-2401 2010
Holmes GP, McCormick JB, Trock SC, Chase RA, Lewis SM, Mason CA, Hall PA, Brammer LS, Perez-Oronoz GI, McDonnell MK, et al. 1990. Lassa fever in the United States. Investigation of a case and new guidelines for management. N Engl J Med. 323(16):1120-3.
Haas WH, Breuer T, Pfaff G, Schmitz H, Köhler P, Asper M, Emmerich P, Drosten C, Gölnitz U, Fleischer K, Günther S. 2003. Imported Lassa fever in Germany: surveillance and management of contact persons. 15;36(10):1254-8
Qi, X et al. Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature. 468:779-784 2010
Fechter & Brownlee. Recognition of mRNA cap strucutres by viral and cellular proteins. Journal of General Virology. 2005. 86: 1239-1249
Reported Structures:
Please click on the MMDB† and PDB† links for relevant structure database entries.
Monomer
Lassa Fever Virus Nucleoprotein Complexed With UTP (MMDB, PDB)
Lassa Fever Virus Nucleoprotein Complexed With dTTP (MMDB, PDB)
Crystal Structure Of Lassa Fever Virus Nucleoprotein In Complex With Mn2+ (MMDB, PDB)
Nucleoprotein Structure Of Lassa Fever Virus (MMDB, PDB)
Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G.D., Ly, H., Liang, Y., Dong, C. (SSPF†)
C-Domain
Exonuclease Domain Of Lassa Virus Nucleoprotein Bound To Manganese (MMDB, PDB)
Exonuclease Domain Of Lassa Virus Nucleoprotein (MMDB, PDB)
Hastie, K.M., Kimberlin, C.R., Zandonatti, M.A., MacRae, I.J., Ollmann, E.O.
Fechter & Brownlee. Recognition of mRNA cap strucutres by viral and cellular proteins. Journal of General Virology. 2005. 86: 1239-1249
Reported Structures:
Please click on the MMDB† and PDB† links for relevant structure database entries.
Monomer
Lassa Fever Virus Nucleoprotein Complexed With UTP (MMDB, PDB)
Lassa Fever Virus Nucleoprotein Complexed With dTTP (MMDB, PDB)
Crystal Structure Of Lassa Fever Virus Nucleoprotein In Complex With Mn2+ (MMDB, PDB)
Nucleoprotein Structure Of Lassa Fever Virus (MMDB, PDB)
Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G.D., Ly, H., Liang, Y., Dong, C. (SSPF†)
C-Domain
Exonuclease Domain Of Lassa Virus Nucleoprotein Bound To Manganese (MMDB, PDB)
Exonuclease Domain Of Lassa Virus Nucleoprotein (MMDB, PDB)
Hastie, K.M., Kimberlin, C.R., Zandonatti, M.A., MacRae, I.J., Ollmann, E.O.
† Glossary:
MMDB - Molecular Modelling Database
PDB - Protein Data Bank
SSPF - Scottish Structural Proteomics Facility
MMDB - Molecular Modelling Database
PDB - Protein Data Bank
SSPF - Scottish Structural Proteomics Facility
Michaela Lelke, Linda Brunotte, Carola Busch, and Stephan Gu ̈nther. An N-Terminal Region of Lassa Virus L Protein Plays a Critical Role in Transcription but Not Replication of the Virus Genome. Journal of Virology. Feb 2010. 84:1934-1944